1、Grignard Reagent: Organo-Mg compounds,Like Organolithium compounds, but milder: Ionic character, electron-deficient oligomeric or polymeric structures Basic and nucleophilic Mg: applications in organic synthesis (Grignard reagents !) Be: extremely toxic, not used Reducing sometimes unwanted side rea 。

2、ctions Organo Ca, Sr, . compounds: ionic, insoluble, not used,Grignard reagents RMgX,Direct synthesis (Grignard reaction): Mechanism is not simple! almost certainly involves SET (Single Electron Transfer) very sensitive to traces of impurities (Na, K, transition metals) in the Mg(vendors sell specia 。

【无机化学|无机化学英文课件：Grignard】3、l Grignard quality Mg containing 1-2% Na/K) nature of the Mg surface is important(for less reactive halides, surface activation is essential: I2, BrCH2CH2Br, MeI or HgCl2,Grignard reagents RMgX,Reactivity: I Br Cl F Selectivity: I gives largest amounts of side products In ethers: In Et2O cleaner tha 。

4、n in THF, but also slower Also in ether/hydrocarbon mixtures Side reactions: Wurtz coupling, especially for allylic halides Radical rearrangements,Grignard reagents RMgX,Main application: addition to polar C=X bonds C=O, C=N, CN Sometimes radical mechanism(especially for aromatic ketones): same prod 。

5、uct expected, but possibly different side products,Mg w/ Mg(OH)2 outerlayer,reaction through channel-defects,RX,anodic/cathodic sites to allow for reduction and release of Mg2+ into solution,Pathway X or absorbed radicals,Pathway R at least some diffusion,R in solution,No intermediate R or EXTREMELY short-lived (mainly speculation at this point) surface bound? - what does that really mean 。

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标题：无机化学|无机化学英文课件：Grignard